Kolkata: Taking Vitamin D supplements could prevent
the development of heart disease in chronic kidney disease patients, a study
said on Thursday, 5th November 2015.
-- which is both a vitamin and a hormone -- helps control levels of calcium and
phosphate in blood and is essential for the formation of bones and teeth.
study by researchers from the George Institute for Global Health in New Delhi
and the Postgraduate Institute of Medical Education and Research in Chandigarh
found that nutritional Vitamin D supplementation improved vascular function and
reduced inflammation in patients with early stage of chronic kidney disease.
findings were presented at the ongoing American Society of Nephrology Kidney
Week 2015 (November 3 - November 8) in San Diego, US.
D deficiency is common in patients with chronic kidney disease. Our study shows
that simply identifying and correcting this abnormality has the potential to
improve the outcomes in these patients," said Vivek Kumar, nephrologist at
the Chandigarh institute and the first author of the study.
in 10 people suffer from chronic kidney disease around the world. Most of these
patients are destined to develop premature cardiovascular disease, said
Vivekanand Jha, leader of the study group.
randomised controlled trial under direct supervision the researchers gave two
doses of 300,000 units of Vitamin D to one group of patients 8 weeks apart
whereas the patients in the other group received matching placebo.
is cheap and widely available, and through its favorable effects on
inflammatory and immune functions, it has the potential to favorably influence
the outcome in these patients, said the researchers.
study has shown improvement in a range of parameters in Vitamin D-treated
patients. What makes this finding of special importance is that patients in
both groups were already on optimal treatment to reduce cardiovascular risk,
hence the benefit of Vitamin D was additive," Jha added.
percent of patients receiving Vitamin D demonstrated significant improvement in
their vascular functions and improvement in biomarkers indicating reduction in
the level of inflammatory and immune activation.
placebo arm, only 5 percent patients showed improved vascular function and
there was no change in the inflammatory and immune markers. Neither the
patients nor the study doctors were aware of which patients received which
treatment till the conclusion of the study, the researchers said.